隋广超教授，博士生导师。
联系方式：
E-mail: gcsui@nefu.edu.cn
电话：86-451-8219-1081
地址：黑龙江省哈尔滨市香坊区和兴路26号
金沙9001cc以诚为本首页(新逸夫教学楼) 117房间
教育和训练经历:
1983/09－1987/07，北京大学，生物系，生物化学专业学士
1990/10－1995/07，北京大学，金沙9001cc以诚为本首页，生物化学及分子生物学博士
1995/10－1998/11，瑞典Karolinska医学院，临床化学系，医学博士
1998/11－1999/07，瑞典Karolinska医学院，临床化学系，博士后
1999/07－2004/08，美国哈佛大学哈佛医学院，病理系，博士后
工作经历:
2004/09－2005/08，美国哈佛大学哈佛医学院，讲师
2005/09－2012/09，美国Wake Forest大学医学院癌症生物学系，美国NIH综合癌症研究中心，助教授
2012/10－2014/06，美国Wake Forest大学医学院癌症生物学系，美国NIH综合癌症研究中心，副教授
2014－现在，金沙9001cc以诚为本首页，教授（全职）
专业特长:
分子生物学，生物化学，细胞生物学，遗传学及表观遗传学，非编码RNA (noncoding RNA)，基因表达及调控，癌症生物学。
研究经验和研究领域:
1）药用植物抑癌活性成分的药效机理研究：药用植物中的很多成分具有抑癌活性，但其药效机理不明，限制其临床应用。为突破该瓶颈，我们将探究植物药用成分在肝癌细胞内的分子靶点、所影响的重要基因及细胞生物途径，创立科学的联合给药方式以有效抑制肝癌发展并降低对机体副作用。首次在细胞水平验证了鞣花酸联合阿霉素或联合顺铂的抗肝癌活性，并在小鼠模型中鉴定了鞣花酸联合阿霉素使用，可以显著加强阿霉素抗肝癌活性，减弱由高浓度下阿霉素引发的心肌毒性。此外，我们还研究了百里香琨，地榆皂苷II的植物天然活性物质的抑癌活性。
2）发明了以DNA载体为基础的RNA干扰（RNAi）技术（即shRNA方法）。这一技术的发明为许多生物学科的研究提供了全新的方法，尤其是对基因和蛋白质功能的研究具有重大的创新性，也进了RNAi技术在医疗上的应用。目前，这一方法已经成为世界范围实验室用于研究基因功能的常规实验技术。该方法的DNA载体成为Ambion/Life Technologies公司的第一代产品（商品名pSilencer）。做为第一作者的相关PNAS文章已被引用上千次。
3）利用对Yin Yang 1（YY1）蛋白在肿瘤发生中功能的研究来探索几种常见癌症（乳腺癌，前列腺癌，肺癌）的致病机制。我的多年的研究成果确立了YY1的癌基因地位。作为一个多功能蛋白，YY1在癌症发生中的终极作用一直有争议。我在2004年发表的Cell文章中发现了YY1对p53的负调控，奠定了YY1的癌基因的地位。这些研究进一步确定YY1的癌基因地位，并揭示了YY1在癌症治疗中作为靶基因的可能性。通过干扰YY1与癌蛋白之间相互作用以抑制肿瘤生长的多肽已被授权专利。
4）对其它抑癌基因、原癌基因及非编码RNA的研究：（1）利用基因芯片等方法对抑癌基因SOX7的研究，发现其上、下游调控因子及可能的调节机制；（2）对DMTF1研究，发现了这一基因产生mRNA的不同选择性剪接（alternative splicing）形态对乳腺癌发生和发展具有完全相反的作用，以及调节该可变剪接的分子机制；（3）研究了几种microRNA对原癌基因EZH2、YY1和FASN的调节作用；（4）利用多个乳腺癌及它们对应的癌旁组织样品中的长非编码RNA（lncRNA）的分析，发现了多种在乳腺癌中差异性表达的lncRNA，目前正在对它们的生物学意义和对乳腺癌的调节功能进行鉴定。
教学情况:
（1）曾经在Wake Forest大学医学院授课：Oncogenes, Tumor suppressors, Cancer Epigenetics, Non-coding RNAs.
（2）表观遗传学与应用（本科生必修课）
（3）留学生课程（全英语）：
1）Epigenetics (Cancer-related)
2）Developmental Biology (Animal)
3）Molecular Biology and Biochemistry
（4）博士生：“生物专业英语”，“动物细胞分子调控”，硕士生：“动物表观遗传学”，“高级生化与分子生物学实验技术”。
（5）作为iGEM (International Genetic Engineering Machine Competition)主要指导和培训教师，曾获2014-2016年iGEM银奖；2018年最佳单项奖；2017-2023年iGEM金奖，2021年“最佳wiki制作”单项奖和“最佳医疗诊断项目”赛道奖。
（6）作为iDEC (International Directed Evolution Competition)主要指导和培训教师，曾获2021年iDEC铜奖，2022年iDEC金奖。
基金评审经历(专家评委, Scientist Reviewer):
*美国国防部(DOD)癌症研究基金评委(2007-2017; 12次)
*美国癌症协会(ACS)研究基金评委(2013)
*意大利健康部(2010, 2013, 2015, 2017)
*英国研究基金(2012)
*美国佛罗里达健康部门基金(2015, 2016)
*中国国家自然科学基金(2019-2022)
*科技部政府间国际科技创新合作和科技部重点研发项目评审(2021)
*科技部前沿生物技术重点专项项目评审(2022)
近年承担的主要课题:
*国家自然科学基金(项目主持人): 2023年01月至2026年12月
题目：乳腺癌中调节DMTF1前体mRNA可变剪接的剪接因子及其分子机制的系统研究
*国家自然科学基金(项目主持人): 2019年01月至2022年12月
题目：乳腺癌细胞基因组内G-四链体的形成特征及调节因素研究
*国家自然科学基金(项目主持人): 2017年01月至2020年12月
题目:乳腺癌中YY1调节促癌蛋白活性的机制及其应用价值的研究
*国家自然科学基金(项目主持人): 2015年01月至2018年12月
题目: SOX7在乳腺癌中调控机制的研究
*黑龙江省自然科学基金重点项目(项目主持人): 2015年07月至2018年06月
题目:利用YY1的OPB肽段抑制肿瘤细胞生长
在美国期间承担过的研究项目(项目主持人: Guangchao Sui)：
*美国National Institute of Health (NIH): R01, 2009 - 2014
项目主持人(PI): Guangchao Sui
题目: Dmp1-p53/YY1 interplays and their roles in lung cancer development
*美国American Cancer Society (ACS)：Research Scholar Grant, 2009 - 2013
项目主持人(PI): Guangchao Sui
2009 – 2013：The role of YY1 in prostate cancer
其它：
*美国Department of Defense (DOD)前列腺癌研究项目
* Golfers Against Cancer (GAC)
* Kulynych Interdisciplinary Cancer Research Fund
* Cell Growth and Survival Program Push Grant
发表文章: (*为通讯作者)
（被评为2023年爱思唯尔“中国高被引学者”）
1. Liying Shan, Wenmeng Wang, Lijuan Du, Dangdang Li, Yunxuan Wang, Yuyan Xie, Hongyan Li, Jiale Wang, Zhihao Shi, Yang Zhou, DaLing Zhu, Guangchao Sui* and Fang Liu*. SP1 undergoes phase separation and activates RGS20 expression through super-enhancers to promote lung adenocarcinoma progression. Proc. Natl. Acad. Sci. USA, 2024, 121(29):e2401834121.
https://doi.org/10.1073/pnas.2401834121
2. Zhenzhao Sun, Ming Wang, Wenmeng Wang, Dangdang Li, Jingfei Wang*, and Guangchao Sui*. Getah Virus Capsid Protein Undergoes Co-condensation with Viral Genomic RNA to Facilitate Virion Assembly. Int J Biol Macromol. 2024, 265:130847.
https://doi.org/10.1016/j.ijbiomac.2024.130847
3. Wenmeng Wang, Dangdang Li*, Qingqing Xu, Jiahui Cheng, Zhiwei Yu, Guangyue Li, Shiyao Qiao, Jiasong Pan, Hao Wang, Jinming Shi, Tongsen Zheng and Guangchao Sui*. G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis. Nat Commun. 2024, 15:1045.
https://doi.org/10.1038/s41467-024-45353-5
4. Hongxuan Du, Yaoyao Liang, Jianing Li, Xinyao Yuan, Fenglin Tao, Chengjie Dong, Zekai Shen, Guangchao Sui* and Pengchao Wang* Directed Evolution of 4-Hydroxyphenylpyruvate Biosensors Based on a Dual Selection System. Int J Mol Sci. 2024, 25:1533.https://doi.org/10.3390/ijms25031533
5. Guangyue Li, Gongbo Su, Yunxuan Wang, Wenmeng Wang, Jinming Shi, Dangdang Li and Guangchao Sui*. Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation. Commun Biol. 2023, 10;6(1):625.
https://doi.org/10.1038/s42003-023-05015-6
6. Jiahui Cheng, Guangyue Li, Wenmeng Wang, Daniel B Stovall, Guangchao Sui*, Dangdang Li*. Circular RNAs with protein-coding ability in oncogenesis. Biochim Biophys Acta Rev Cancer. (2023) 1878(4):188909.
https://doi.org/10.1016/j.bbcan.2023.188909
7. Umar Farooq, Hao Wang, Jingru Hu, Guangyue Li, Shah Jehan, Jinming Shi, Dangdang Li* and Guangchao Sui*. Polydatin Inhibits Hepatocellular Carcinoma Cell Proliferation and Sensitizes Doxorubicin and Cisplatin through Targeting Cell Mitotic Machinery. Cells. (2023) 2023, 12(2):222.
https://doi.org/10.3390/cells12020222
8. Wenmeng Wang, Shiyao Qiao, Guangyue Li, Jiahui Cheng, Cuicui Yang, Chen Zhong, Daniel B. Stovall, Jinming Shi, Chunbo Teng, Dangdang Li* and Guangchao Sui*. A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters. Nucleic Acids Res. (2022) 50(9):4917-4937.
https://doi.org/10.1093/nar/gkac233
9. Shiyao Qiao, Wenmeng Wang, Cheng Yi, Qingqing Xu, Wenfei Wang, Jinming Shi, Daniel B. Stovall, Dangdang Li and Guangchao Sui*. YY1 Oligomerization Is Regulated by Its OPB Domain and Competes with Its Regulation of Oncoproteins. Cancers. (2022) 14, 1611.
https://doi.org/10.3390/cancers14071611
10. Yaoyao Liang, Juan Luo, Chenhao Yang, Shuning Guo, Bowen Zhang, Fengqianrui Chen, Kairui Su, Yulong Zhang, Yi Dong, Zhihao Wang, Hongda Fu, Guangchao Sui* and Pengchao Wang*. Directed evolution of the PobR allosteric transcription factor to generate a biosensor for 4-hydroxymandelic acid. World J Microbiol Biotechnol. (2022) 38(6):104.
https://doi.org/10.1007/s11274-022-03286-5
11. Lin Zhang, Shubo Wang, Wenmeng Wang, Jinming Shi, Daniel B. Stovall, Dangdang Li,* and Guangchao Sui*. Phase-Separated Subcellular Compartmentation and Related Human Diseases. Int J Mol Sci. (2022) 23(10):5491.
https://doi.org/10.3390/ijms23105491
12. Jinhua Wang, Dangdang Li, Bo Zhao, Juhyok Kim, Guangchao Sui* and Jinming Shi*. Small Molecule Compounds of Natural Origin Target Cellular Receptors to Inhibit Cancer Development and Progression. Int J Mol Sci. (2022) 23:2672.
https://doi.org/10.3390/ijms23052672
13. Cheng Yi, Guangyue Li, Wenmeng Wang, Yixuan Sun, Yueling Zhang, Chen Zhong, Daniel B. Stovall, Dangdang Li, Jinming Shi* and Guangchao Sui*. Disruption of YY1-EZH2 Interaction Using Synthetic Peptides Inhibits Breast Cancer Development. Cancers. (2021) 13(10):2402.
http://dx.doi.org/doi:10.3390/cancers13102402
14. Jialiang Li, Guangyue Li, Yige Qi, Yao Lu, Hao Wang, Ke Shi, Dangdang Li, Jinming Shi, Daniel B. Stovall and Guangchao Sui*. SRSF5 Regulates Alternative Splicing of DMTF1 pre-mRNA through Modulating SF1 Binding. RNA Biology. (2021) 18(sup1):318-336.
http://dx.doi.org/doi:10.1080/15476286.2021.1947644
15. Aixin Hao, Yunxuan Wang, Daniel B. Stovall, Yu Wang* and Guangchao Sui*. Emerging Roles of LncRNAs in the EZH2-regulated Oncogenic Network. Int J Biol Sci. (2021)17(13):3268-3280.
http://dx.doi.org/doi:10.7150/ijbs.63488
16. Bo Zhao, Jinyan Zhao, Mingshuai Lv, Xiaoyan Li, Jinhua Wang, Zhengrong Yue, Jinming Shi, Guocai Zhang* and Guangchao Sui*. Comparative study of structural properties and biological activities of polysaccharides extracted from Chroogomphus rutilus by four different approaches. Int J Biol Macromol. (2021)188:215-225.
http://dx.doi.org/doi:10.1016/j.ijbiomac.2021.08.025
17. Aixin Hao, Yu Wang, Xiao Zhang, Jialiang Li, Yingzhou Li, Dangdang Li, George Kulik and Guangchao Sui*. Long Non-coding Antisense RNA HYOU1-AS is Essential to Human Breast Cancer Development Through Competitive Binding hnRNPA1 to Promote HYOU1 Expression. Biochim Biophys Acta - Mol Cell Res. (2021) 1868(4):118951.
http://dx.doi.org/doi:10.1016/j.bbamcr.2021.118951
18. Qiong Wu, Bo Zhao, Guangchao Sui* and Jinming Shi*. Phytochemicals block glucose utilization and lipid synthesis to counteract metabolic reprogramming in cancer cells. Applied Sciences.(2021) 11:1259.
https://doi.org/10.3390/app11031259
19. Albert Gyapong Aduhene, Hongliang Cui, Hongyi Yang, Chengwei Liu, Guangchao Sui* and Changli Liu*. Poly(3-hydroxypropionate): Biosynthesis Pathways and Malonyl-CoA Biosensor Material Properties. Front Bioeng Biotech.(2021) 9:646995.
http://dx.doi.org/doi:10.3389/fbioe.2021.646995
20. Shuang Qiu, Chen Zhong, Bo Zhao, Guangyue Li, Jinhua Wang, Shah Jehan, Jialiang Li, Xudong Zhao, Dangdang Li and Guangchao Sui*. Transcriptome Analysis of Signaling Pathways Targeted by Ellagic Acid in Hepatocellular Carcinoma Cells.Biochim Biophys Acta – General Subjects. (2021) 1865(7):129911.
http://dx.doi.org/doi:10.1016/j.bbagen.2021.129911
21. Lanlan Zhang, Ting Yan, Wenmeng Wang, Qiong Wu, Guangyue Li, Dangdang Li, Daniel B Stovall, Yunxuan Wang, Yuhua Li* and Guangchao Sui*. AKT1 is positively regulated by G-quadruplexes in its promoter and 3'-UTR. Biochem Biophys Res Commun. (2021) 561:93-100.
http://dx.doi.org/doi:10.1016/j.bbrc.2021.05.029
22. Yunxuan Wang, Ting Yan, Jialiang Li, Wenmeng Wang, Qiong Wu, Jinming Shi, Dangdang Li, Daniel B. Stovall, Qingyuan Zhang* and Guangchao Sui*. The SNAIL1 promoter contains G-quadruplex structures regulating its gene expression and DNA replication. Exp Cell Res. (2020) 394(2):112158.
http://dx.doi.org/doi:10.1016/j.yexcr.2020.112158
23. Wenmeng Wang, Shuangli Hu, Yaru Gu, Yunxiao Yan, Daniel B. Stovall, Dangdang Li* and Guangchao Sui*. Human MYC G-quadruplex: From discovery to a cancer therapeutic target. Biochim Biophys Acta - Rev Cancer. (2020) 1874(2):188410.
http://dx.doi.org/doi:10.1016/j.bbcan.2020.188410
24. Shah Jehan, Chen Zhong, Guangyue Li, Syed Zulqarnain Bakhtiar, Dangdang Li* and Guangchao Sui*. Thymoquinone selectively induces hepatocellular carcinoma cell apoptosis in synergism with clinical therapeutics and dependence of p53 status. Front Pharmacol., (2020) 11:555283.
http://dx.doi.org/doi:10.3389/fphar.2020.555283
25. Sazzad Hassan, Ashok Pullikuth, Kyle C Nelson, Anabel Flores, Yelena Karpova, Daniele Baiz, Sinan Zhu, Guangchao Sui, Yue Huang, Ralph D'Agostino, Ashok Hemal, Urs von Holzen, Waldemar Debinski and George Kulik. Beta2-adrenoreceptor signaling increases therapy-resistance in prostate cancer by upregulating MCL1. Mol Cancer Res, (2020) 18(12):1839-1848.
http://dx.doi.org/doi:10.1158/1541-7786.MCR-19-1037
26. Jialiang Li, Ke Shi, Tianqi Xu, Jingru Hu, Tianxin Li, Guangyue Li, Kuida Chen, Dangdang Li, Kazushi Inoue and Guangchao Sui*. Mechanisms regulating DMTF1β/γ expression and their functional interplay with DMTF1α. Int J Oncol., (2020) 58(1):20-32.
http://dx.doi.org/doi:10.3892/ijo.2020.5146
27. Ting Yan, Bo Zhao, Qiong Wu, Wenmeng Wang, Jinming Shi, Dangdang Li, Daniel B. Stovall and Guangchao Sui*. Characterization of G-quadruplex formation in the ARID1A promoter. Int J Biol Macromol. (2020) 147:750-761.
http://dx.doi.org/doi:10.1016/j.ijbiomac.2020.01.210
28. Dangdang Li, Daniel B. Stovall B, Wenmeng Wang and Guangchao Sui*. Advances of Zinc Signaling Studies in Prostate Cancer. Int J Mol Sci. (2020) 21(2):667.
http://dx.doi.org/doi:10.3390/ijms21020667
29. Yige Qi, Ting Yan, Lu Chen, Qiang Zhang, Weishu Wang, Xu Han, Dangdang Li, Jinming Shi and Guangchao Sui*. Characterization of YY1 OPB Peptide for Its Anticancer Activity, Current Cancer Drug Targets, (2019) 19(6):504-511.
http://dx.doi.org/doi:10.2174/1568009618666181031153151
30. Chen Zhong, Shuang Qiu, Jialiang Li, Jingling Shen, Yuangang Zu, Jinming Shi* and Guangchao Sui*. Ellagic acid synergistically potentiates inhibitory activities of chemotherapeutic agents to human hepatocellular carcinoma.Phytomedicine, (2019) 59:152921.
http://dx.doi.org/doi:10.1016/j.phymed.2019.152921
31. Kuida Chen, Yao Lu, Ke Shi, Daniel B. Stovall, Dangdang Li and Guangchao Sui*. Functional analysis of YY1 zinc fingers through cysteine mutagenesis. FEBS Letters, (2019) 593(12):1392-1402.
http://dx.doi.org/doi:10.1002/1873-3468.13431
32. Shuting Lu, Liping Liu, Henan Wang, Wancheng Zhao, Zeyu Li, Zheng Qu, Jialu Li, Tiedong Sun, Ting Wang and Guangchao Sui. Synthesis of dual functional gallic-acid-based carbon dots for bioimaging and antitumor therapy. Biomaterials Science, (2019) 7(8):3258-3265.
http://dx.doi.org/doi:10.1039/c9bm00570f
33. Yumeng Zhang, Daniel B. Stovall, Meimei Wan, Qiang Zhang, Jeff W. Chou, Dangdang Li and Guangchao Sui*. SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function. Int. J. Mol. Sci. (2018) 19(5):pii: E1451.
http://dx.doi.org/doi:10.3390/ijms19051451
34. Yingzhou Li, Xiao Zhang, Yang Gao, Jiming Shi, Liping Tang* and Guangchao Sui*. G-quadruplexes in the BAP1 promoter positively regulate its expression. Exp. Cell. Res. (2018) 369(1):147-15.
http://dx.doi.org/doi:10.1016/j.yexcr.2018.05.016
35. Jeffrey P Chmielewski, Sarah Bowlby, Frances Wheeler, Lihong Shi, Guangchao Sui, Amanda L. Davis, Timothy Howard, Ralph B. D'Agostino, Lance Miller, S. Joseph Sirintrapun, Scott Cramer and Steven J. Kridel. CD38 Inhibits Prostate Cancer Metabolism and Proliferation by Reducing Cellular NAD+ Pools. Mol. Cancer. Res. (2018) 16(11):1687-1700.
http://dx.doi.org/DOI:10.1158/1541-7786.MCR-17-0526
36. Xiao Zhang, Bo Zhao, Ting Yan, Aixin Hao, Yang Gao, Dangdang Li and Guangchao Sui*. G-Quadruplex Structures at the Promoter of HOXC10 Regulate its Expression. BBA-Gene Regul. Mech., (2018) 1861(11):1018-1028.
http://dx.doi.org/doi:10.1016/j.bbagrm.2018.09.004
37. Na Tian, Jialiang Li, Jinming Shi and Guangchao Sui*. From General Aberrant Alternative Splicing in Cancers and Its Therapeutic Application to the Discovery of an Oncogenic DMTF1 Isoform. (2017) Int. J. Mol. Sci. 18(191):1-20.
http://dx.doi.org/doi:10.3390/ijms18030191
38. Wenmeng Wang, Dangdang Li and Guangchao Sui*. YY1 Is an Inducer of Cancer Metastasis. Crit. Rev. Oncog. (2017) 22(1-2):1-11.
http://dx.doi.org/doi:10.1615/CritRevOncog.2017021314
39. Li Yao*, Heming Wang, Yuanyuan Song and Guangchao Sui*. BioQueue: a novel pipeline framework to accelerate bioinformatics analysis. Bioinformatics. (2017) 33(20):3286-3288.
http://dx.doi.org/doi:10.1093/bioinformatics/btx403
40. Chen Zhong, Nathan R. Wall, Yuangang Zu and Guangchao Sui*. Therapeutic Application of Natural Medicine Monomers in Cancer Treatment. Curr. Med. Chem. (2017) 24(34):3681-3691.
http://dx.doi.org/doi:10.2174/0929867324666170714101503
41. Qiang Zhang, Meimei Wan, Jinming Shi, David A. Horita, Lance D. Miller, Timothy E. Kute, Steven J. Kridel, George Kulik, and Guangchao Sui*. Yin Yang 1 Promotes mTORC2-mediated AKT Phosphorylation. J. Mol. Cell. Biol. (2016) 8(3):232-243.
http://dx.doi.org/doi:10.1093/jmcb/mjw002
42. Jingxuan Wang, Xiao Zhang, Jinming Shi, Paul Cao, Meimei Wan, Qiang Zhang, Yunxuan Wang, Steven J. Kridel, Wennuan Liu, Jianfeng Xu, Qingyuan Zhang and Guangchao Sui*. Fatty Acid Synthase is a Primary Target of MiR-15a and MiR-16-1 in Breast Cancer. Oncotarget. (2016) 7(48):78566-78576.
http://dx.doi.org/doi:10.18632/oncotarget.12479
43. Dejan Maglic, Daniel B. Stovall, Mark Cline, Elizabeth A. Fry, Ali Mallakin, Pankaj Taneja, David L. Caudell, Mark C. Willingham, Guangchao Sui*, and Kazushi Inoue*. DMP1β, a splice isoform of the tumor suppressor DMP1 locus, induces proliferation and progression of breast cancer. J. Pathol.(2015) 236(1):90-102.
http://dx.doi.org/doi:10.1002/path.4504
44. Jinming Shi, Aixin Hao, Qiang Zhang, and Guangchao Sui*. The Role of YY1 in Oncogenesis and Its Potential as a Drug Target in Cancer Therapies. Current Cancer Drug Targets. (2015) 15(2):145-157.
http://dx.doi.org/10.2174/1568009615666150131124200
45. Wei Wang, Zhiyong Deng, Heather Hatcher, Lance D. Miller, Xiumin Di, Lia Tesfay, Guangchao Sui, Ralph B. D'Agostino Jr., Frank M. Torti, and Suzy V. Torti.IRP2 regulates breast tumor growth. Cancer Research. (2014) 74(2):497-507.
http://dx.doi.org/doi:10.1158/0008-5472.CAN-13-1224
46. Nicholas R. Galloway, Carlos J. Diaz Osterman, Karl Reiber, Jessica M.S. Jutzy, Fengzhi Li, Guangchao Sui, Ubaldo Soto, Nathan R. Wall. Yin Yang 1 regulates the transcriptional repression of surviving. Biochem Biophys Res Commun. (2014) 445(1):208-213.
http://dx.doi.org/doi:10.1016/j.bbrc.2014.01.169
47. Daniel B. Stovall, Paul Cao and Guangchao Sui*.SOX7: From a developmental regulator to an emerging tumor suppressor. Histol Histopathol. (2014) 29(4):439-445.
http://www.hh.um.es/Abstracts/Vol_29/29_4/29_4_439.htm
48. Wei Wang, David Grier, Jennifer Woo, Martha Ward, Guangchao Sui, Suzy V. Torti, Frank M. Torti, and Michael W. Beaty.Ferritin H is a novel marker of early erythroid precursors and macrophages. Histopathology. (2013) 62(6):931-40.
http://dx.doi.org/ doi:10.1111/his.12101
49. Sinan Zhu, Ryan T. Mott, Elizabeth A. Fry, Pankaj Taneja, George Kulik, Guangchao Sui*, and Kazushi Inoue*.Cooperation between Dmp1-loss and cyclin D1 overexpression in breast cancer. American Journal of Pathology. (2013) 183(4):1339-1350.
http://dx.doi.org/doi:10.1016/j.ajpath.2013.06.027
50. Daniel B. Stovall, Meimei Wan, Lance D. Miller, Paul Cao, Dejan Maglic, Qiang Zhang, Martha R. Stampfer, Wennuan Liu, Jianfeng Xu and Guangchao Sui*.The Regulation of SOX7 and its Tumor Suppressive Role in Breast Cancer. American Journal of Pathology. (2013) 183(5):1645-1653.
http://dx.doi.org/doi:10.1016/j.ajpath.2013.07.025
51. DanaYancey, Kyle C. Nelson, Daniele Baiz, Sazzad Hassan, Anabel Flores, Ashok Pullikuth, Yelena Karpova, Victoria Moore1, Guangchao Sui and George Kulik.BAD Dephosphorylation and Decreased Expression of MCL-1 Induce Rapid Apoptosis in Prostate Cancer Cells. PLoS One. (2013) 8(9):e74561.http://dx.doi.org/doi:10.1371/journal.pone.0074561
52. Daniele Baiz, Sazzad Hassan, Young AChoi, Anabel Flores, Yelena Karpova, Dana Yancey, Ashok Pullikuth, Guangchao Sui, Michel Sadelain, Waldemar Debinski and George Kulik.Combination of the PI3K Inhibitor ZSTK474 with a PSMA-Targeted Immunotoxin Accelerates Apoptosis and Regression of Prostate Cancer. Neoplasia. (2013) 15(10):1720-1183.
http://dx.doi.org/doi:10.1593/neo.13986
53. Elizabeth A. Fry, Pankaj Taneja, Dejan Maglic, Sinan Zhu, Guangchao Sui*, and Kazushi Inoue*.Dmp1α Inhibits HER2/neu-induced Mammary Tumorigenesis. PLoS One. (2013) 8(10):e77870.
http://dx.doi.org/doi:10.1371/journal.pone.0077870
54. Guorui Deng and Guangchao Sui*.Noncoding RNA in Oncogenesis: A New Era of Identifying Key Players. Int. J. Mol. Sci. (2013) 14:18319-18349. (Invited review)
http://dx.doi.org/doi:10.3390/ijms140918319
55. Weiwei Huang, Philip J. Smaldino, Qiang Zhang, Lance D. Miller, Paul Cao, Kristin Stadelman, Meimei Wan, Banabihari Giri, Ming Lei, Yoshikuni Nagamine, James P. Vaughn, Steven A. Akman and Guangchao Sui*.Yin Yang 1 contains G-quadruplex structures in its promoter and 5’-UTR and its expression is modulated by G4 Resolvase 1. Nucleic Acids Research, (2012) 40(3):1033-1049.
http://dx.doi.org/doi:10.1093/nar/gkr849
56. Shihua Wang, Jiansheng Wu, Janel Suburu, Zhennan Gu, Jiaozhong Cai, Linara S. Axanova, Scott D. Cramer, Michael J. Thomas, Donna L. Perry, Iris Edwards, Lorelei Mucci, Jennifer Sinnott, Massimo Loda, Guangchao Sui, Isabelle M. Berquin and Yong Q. Chen. Effect of Dietary Polyunsaturated Fatty Acids on Castration-resistant Pten-null Prostate Cancer. Carcinogenesis, (2012) 33(2):404-412.
http://dx.doi.org/doi:10.1093/carcin/bgr290
57. Wennuan Liu, Johan Lindberg, Guangchao Sui, Jun Luo, Tao Li, Carol Xie, Meimei Wan, Seong-Tae Kim, Aubrey Turner, Jishan Sun, Yi Zhu, Zheng Zhang, Scott D Cramer, Robert L. Vessella, S. Lilly Zheng, Henrik Grönberg, William B. Isaacs and Jianfeng Xu.Genome-wide analysis of somatic DNA copy number reveals novel CHD1-associated collaborative alterations of genomic structure in prostate cancer. Oncogene, (2012) 31(35):3939-48.
http://dx.doi.org/doi:10.1038/onc.2011.554
58. Caroline I. Schnegg, Mitra Kooshki, Fang-Chi Hsu, Guangchao Sui and Mike E. Robbins. PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-кB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway. Free Radical Biology and Medicine, (2012) 52:1734-1743.
http://dx.doi.org/10.1016/j.freeradbiomed.2012.02.032
59. Donna P. Frazier, Robert D. Kendig, Fumitake Kai, Dejan Maglic, Takayuki, Sugiyama, Rachel L. Morgan, Sarah J. Lagedrost, Guangchao Sui and Kazushi Inoue. Dmp1 physically interacts with p53 and positively regulates p53’s stability, nuclear localization and transcriptional activity. Cancer Research, (2012) 72:1740-1750.
http://dx.doi.org/doi:10.1158/0008-5472.CAN-11-2410
60. Meimei Wan, Weiwei Huang, Timothy E. Kute, Lance Miller, Qiang Zhang, Heather Hatcher, Jingxuan Wang, Daniel Stovall, Gregory B. Russell, Paul Cao, Zhiyong Deng, Wei Wang, Qingyuan Zhang, Ming Lei, Suzy Torti, Steven A. Akman and Guangchao Sui*. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. American Journal of Pathology, (2012) 180(5):2120-2133.
http://dx.doi.org/10.1016/j.ajpath.2012.01.037
61. Min Wu, Lihong Shi, Adela Cimic, Lina Romero, Guangchao Sui, Cynthia J. Lees, J. Mark Cline, Darren F. Seals, Joseph S. Sirintrapun, Thomas P. McCoy, Jielin Sun, Seong-Tae Kim, Wennuan Liu, Donna M. Peehl, Jianfeng Xu, Scott D. Cramer.Suppression of Tak1 promotes prostate tumorigenesis. Cancer Research, (2012) 72(11):2833-2843.
http://dx.doi.org/doi:10.1158/0008-5472.CAN-11-2724
62. Shuai Tang, Meenu Mishra, Donna P. Frazier, Miranda L. Moore, Kazushi Inoue, Rajendar Deora, Guangchao Sui and Purnima Dubey. Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines. PLoS One, (2012) 7(4): e35570.
http://dx.doi.org/doi:10.1371/journal.pone.0035570
63. Daniel Stovall and Guangchao Sui*. The Function of YY1 and its Oncogenic Role in Prostate Cancer. In: Gerhard Hamilton, eds.Advances in Prostate Cancer.InTech. 2012:563-587.
http://dx.doi.org/10.5772/53091
64. Daniel Stovall, Meimei Wan, Qiang Zhang, Purnima Dubey and Guangchao Sui*.DNA Vector-based RNA Interference to Study Gene Function in Cancer. Journal of Visualized Experiments, (2012) (64), pii: 4129.
http://dx.doi.org/doi:10.3791/4129
65. Zhiyong Deng, Guangchao Sui, Paulo Mottin Rosa and Weiling Zhao.Radiation-Induced c-Jun Activation Depends on MEK1-ERK1/2 Signaling Pathway in Microglial Cells. PLoS One, (2012) 7(5):e36739.
http://dx.doi.org/doi:10.1371/journal.pone.0036739
66. Zandra K. Pinnix, Lance D. Miller, Wei Wang, Ralph D’Agostino Jr., Tim Kute, Mark C. Willingham, Heather Hatcher, Lia Tesfay, Guangchao Sui, Xiumin Di, Suzy V. Torti, Frank M. Torti.Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis.Sci Transl Med. (2012) 22, 43ra56.
http://dx.doi.org/doi:10.1126/scitranslmed.3001127
67. Salima Daou, Nazar Mashtalir, Ian H Martel, Helen Pak, Helen Yu, Guangchao Sui, Jodi Vogel, Thomas Kristie, El Bachir Affar.Crosstalk Between O-GlcNAcylation And Proteolytic Cleavage Regulates The Host Cell Factor-1 Maturation Pathway. Proc. Natl. Acad. Sci. USA, (2011) 108(7):2747-2752.
http://dx.doi.org/doi:10.1073/pnas.1013822108
68. Sophia L Maund, Wendy W Barclay, Laura D Hover, Linara S Axanova, Guangchao Sui, Jason D Hipp, James C. Fleet, Andrew Thorburn, and Scott D Cramer.Interleukin-1α Mediates the Antiproliferative Effects of 1,25-Dihydroxyvitamin D3 in Prostate Progenitor/Stem Cells. (2011) Cancer Research, 71(15):5276-5286.
http://dx.doi.org/doi:10.1158/0008-5472.CAN-10-2160
69. Qiang Zhang, Daniel Stovall, Kazushi Inoue and Guangchao Sui*.The oncogenic role of Yin Yang 1. Critical Reviews in Oncogenesis, (2011) 16(3-4):163-197. (Invited review)
http://dx.doi.org/DOI:10.1615/CritRevOncog.v16.i3-4.30
90. Rui Fang, Andrew J. Barbera, Yufei Xu, Michael Rutenberg, Thiago Leonor, Qing Bi, Fei Lan, Pinchao Mei, Guo-Cheng Yuan, Christine Lian, Junmin Peng, Dongmei Cheng, Guangchao Sui, Ursula B. Kaiser, Yang Shi and Yujiang Geno Shi.Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation. Mol. Cell, (2010) 39(2):222-233.
http://dx.doi.org/doi:10.1016/j.molcel.2010.07.008
71. Helen Yu, Nazar Mashtalir, Salima Daou, Ian Hammond-Martel, Julie Ross, Guangchao Sui, Gerald W. Hart, Frank J. Rauscher III, Elliot Drobetsky, Eric Milot, Yang Shi and El Bachir Affar.The Ubiquitin Carboxyl Hydrolase BAP1 Forms a Ternary Complex with YY1 and HCF-1 and is a Critical Regulator of Gene Expression.Mol. Cell. Biol., (2010) 30(21):5071-5085.
http://dx.doi.org/doi:10.1128/MCB.00396-10
72. Zhiyong Deng, Paul Cao, Meimei Wan and Guangchao Sui*.Yin Yang 1: a multifaceted protein beyond a transcription factor.Transcription. (2010) 1(2):81-84. (Invited review)
http://dx.doi.org/10.4161/trns.1.2.12375
73. Paul Cao, Zhiyong Deng, Meimei Wan, Weiwei Huang, Scott D Cramer, Jianfeng Xu, Ming Lei and Guangchao Sui*.MicroRNA-101 Negatively Regulates Ezh2 and Its Expression is Modulated by Androgen Receptor and HIF-1alpha/HIF-1beta. Mol. Cancer, (2010) 9(1):108.
http://dx.doi.org/doi:10.1186/1476-4598-9-108
74. Linara S. Axanova, Yong Q. Chen, Thomas McCoy, Guangchao Sui and Scott D. Cramer.1,25-dihydroxyvitamin D3 and PI3K/AKT inhibitors synergistically inhibit growth and induce senescence in prostate cancer cells. Prostate. (2010) 70(15):1658-1671.
http://dx.doi.org/doi:10.1002/pros.21201
75. Zhiyong Deng, Meimei Wan, Paul Cao, Anuradha Rao, Scott D. Cramer and Guangchao Sui*. Yin Yang 1 Regulates the Transcriptional Activity of Androgen Receptor. Oncogene; (2009) 28:3746-3757.
http://dx.doi.org/doi:10.1038/onc.2009.231
76. Guangchao Sui*.The regulation of YY1 in tumorigenesis and its targeting potential in cancer therapy. Mol. Cell. Pharmacol. (2009) 1(3):157-176 (Invited review)
http://dx.doi.org/DOI:10.4255/mcpharmacol.09.20
77. Dohoon Kim, Minh Nguyen, Matthew Dobbin, Andre Fischer, Farahnaz Sananbenesi, Joseph Rodgers, Ivana Delalle, Joseph Baur, Guangchao Sui, Sean M Armour, Pere Puigserver, David Sinclair and Li-Huei Tsai.SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. (2007) 26(13):3169–3179.
http://dx.doi.org/doi:10.1038/sj.emboj.7601758
78. Zhiyong Deng, Meimei Wan and Guangchao Sui*.PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger. Mol. Cell. Biol., (2007) 27(10):3780-3792.
http://dx.doi.org/doi:10.1128/MCB.01761-06
79. Margaret P. Luke, Guangchao Sui, Huifei Liu and Yang Shi.Yin Yang 1 physically interacts with HoxA11 and represses HoxA11-depedent transcription. J. Biol. Chem., (2006) 281:33226-33232.
http://dx.doi.org/doi:10.1074/jbc.M606584200
80. El Bachir Affar, Margaret Po-shan Luke, Frederique Gay, Dominica, Calvo, Guangchao Sui, Robert S. Weiss, En Li, and Yang Shi.Targeted ablation of Par-4 reveals a cell type-specific susceptibility to apoptosis-inducing agents. Cancer Research. (2006) 66:3456-3462.
http://dx.doi.org/doi:10.1158/0008-5472.CAN-05-0964
81. Guangchao Sui and Yang Shi.Gene silencing by a DNA vector-based RNAi technology. Methods Mol. Biol., (2005) 309:205-218.
http://dx.doi.org/doi:10.1385/1-59259-935-4:205
82. Peter Baumeister, Shengzhan Luo, William C. Skarnes, Guangchao Sui, Edward Seto, Yang Shi and Amy S. Lee.Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Mol. Cell. Biol., (2005) 25:4529-4540.
http://dx.doi.org/doi:10.1128/MCB.25.11.4529-4540.2005
83. Guangchao Sui, El Bachir Affar, Yujiang Shi, Chrystelle Brignone, Nathan R. Wall, Peng Yin, Mary Donohoe, Margaret P. Luke, Dominica Calvo, Steven R. Grossman and Yang Shi.Yin Yang 1 is a negative regulator of p53. Cell, (2004) 117:859-872.
http://dx.doi.org/doi:10.1016/j.cell.2004.06.004
84. Yujiang Shi, Junichi Sawada, Guangchao Sui, El Bachir Affar, Johnathan R. Whetstine, Fei Lan, Hidesato Ogawa, Margaret Po-Shan Luke, Yoshihiro Nakatani and Yang Shi.Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature, (2003) 422:735-738.
http://dx.doi.org/doi:10.1038/nature01550
85. Guangchao Sui, Christina Soohoo, El Bachir Affar, Frederique Gay, Yujiang Shi, William C. Forrester, and Yang Shi.A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc. Natl. Acad. Sci. USA, (2002) 99:5515-5520.
http://dx.doi.org/doi:10.1073/pnas.082117599
86. Dominica Calvo, Martin Vector, Frederique Gay, Guangchao Sui, Margaret P Luck, Pascle Dufourcq, Gengyun Wen, M Maduro, J Rothman and Yang Shi.A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during Caenorhabditis elegans embryogenesis. EMBO. J., (2001) 20(24):7197-7208.
http://dx.doi.org/doi:10.1093/emboj/20.24.7197.
87. Guang-Chao Sui and Björn Wiman.The B beta-sheet in the PAI-1 molecule plays an important role in regulating its stability. Thrombosis and Haemostasis, (2000) 83(6):896-901.http://www.schattauer.de/index.php?id=1268&L=1&pii=th00060896&no_cache=1
88. Helena Mångs, Guang-Chao Sui and Björn Wiman.PAI-1 stability: role of histidine residues. FEBS Letters, (2000) 475(3):192-196.
http://dx.doi.org/doi:10.1016/S0014-5793(00)01656-2
89. Guang-Chao Sui, Helena Mångs and Björn Wiman.The role of His143 to PAI-1 function. Biochim. Biophys. Acta., (1999) 1434(1):58-63.
http://dx.doi.org/doi:10.1016/S0167-4838(99)00157-0
90. Gunnar Falk, Guang-Chao Sui, Sam Schulman and Björn Wiman.Detection of a new polymorphism in the propeptide region of the PAI-1 gene in two individuals with bleeding tendencies. Fibrinolysis and Proteolysis, (1999) 13(1):26-30.
http://dx.doi.org/doi:10.1016/S0268-9499(99)90012-7
91. Guang-Chao Sui and Björn Wiman.Functional effects of single amino acid substitutions in the region Phe113 to Asp138 in the PAI-1 molecule. Biochem. J., (1998) 331(2):409-415.
http://www.biochemj.org/bj/331/0409/bj3310409.htm
92. Guang-Chao Sui and Björn Wiman.Stability of plasminogen activator inhibitor-1: role of Tyrosine221. FEBS Letters, (1998) 423(3):319-323.
http://dx.doi.org/doi:10.1016/S0014-5793(98)00115-X
93. Guang-Chao Sui, Hong Sun, Man Zhang and Mei-Hao Hu.High level expression of recombinant plasminogen activator inhibitor-1 in Escherichia coli and generation of its mutants involving Asp125, Glu128 and Glu130. Biochem. Mol. Biol. Int., (1997) 42(3):621-629.
http://www.ncbi.nlm.nih.gov/pubmed/?term=9247720
著作:
Yin Yang 1 in Metastasis, Critical Reviews™ in Oncogenesis, 22(1-2), 2017. Begell House Inc. Invited editor: Guangchao Sui.http://dx.doi.org/doi:10.1615/CritRevOncog.v22.i1-2
发明专利:
1.发明人：Yang Shi and Guangchao Sui. Compositions and Methods of Suppressing Eukaryotic Gene Expression. Publication of US20030180756A1
https://patents.google.com/patent/US20030180756A1/en
2.发明人：隋广超
发明专利：一种具有抗癌活性的OPB寡肽及其表达载体和应用
专利号：ZL 2016 1 0018929.6
授权日期：2019年6月7日
3.发明人：隋广超，易诚，史金铭，李当当
发明专利：利用YPB肽段抑制乳腺癌细胞增殖及肿瘤生长的方法和应用
专利号：ZL 2020 1 1128751.3
授权日期：2022年7月29日
